- What lab markers indicate sepsis?

Lab Markers Indicating Sepsis

Table of Contents

  1. Introduction
  2. Lab Markers Indicating Sepsis
    1. Complete Blood Count (CBC)
    2. C-Reactive Protein (CRP)
    3. Procalcitonin (PCT)
    4. Blood Cultures
    5. Lactate Levels
  3. Joinstar Company Solutions
  4. References

Introduction

Sepsis is a life-threatening condition caused by the body's response to infection, leading to tissue damage, organ failure, and death if not promptly treated. Identifying sepsis early is critical, and specific laboratory markers play a crucial role in its diagnosis. Below, we detail key lab markers that assist healthcare professionals in diagnosing sepsis.

Lab Markers Indicating Sepsis

Complete Blood Count (CBC)

The CBC test measures various components of blood, including White Blood Cell (WBC) count. In sepsis, WBC levels are often elevated (>12,000/μL) or decreased (<4,000/μL), indicating an immune response to infection or immune suppression.

C-Reactive Protein (CRP)

CRP is a marker of inflammation in the body. Levels greater than 100 mg/L are strongly suggestive of sepsis, as CRP rises in response to inflammatory cytokines activated during systemic infection.

Procalcitonin (PCT)

PCT is a precursor of the hormone calcitonin, which increases significantly during bacterial infection. Levels above 2 ng/mL are generally considered indicative of a high risk for sepsis.

Blood Cultures

Blood cultures are essential in identifying the presence and type of bacteria or fungi in the bloodstream. Positive cultures with pathogenic organisms confirm the diagnosis of sepsis, although results can take up to 48 hours.

Lactate Levels

Lactate levels above 2 mmol/L indicate tissue hypoperfusion and are associated with sepsis severity. Increased lactate levels often correlate with higher mortality in sepsis patients.

Joinstar Company Solutions

Joinstar Biomedical Technology Co., Ltd. offers innovative diagnostic solutions for the rapid detection of sepsis markers. Their products include:

  • Joinstar Procalcitonin Rapid Test Kit: Provides quick and accurate measurement of PCT levels, aiding in the early diagnosis of bacterial sepsis.
  • Joinstar CRP Rapid Test Kit: Facilitates the determination of CRP levels in suspected sepsis cases, supporting timely clinical decision-making.
  • Lactate Level Monitoring Devices: Aid in monitoring lactate levels, enabling real-time assessment of sepsis progression and response to treatment.

References

  1. Levy, M. M., et al. (2003). 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference, Critical Care Medicine, 31(4), 1250-1256.
  2. Pinsky, M. R., et al. (2013). Sepsis biomarkers: what and who, Critical Care, 17(5), 240.
  3. Angus, D. C., et al. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care, Critical Care Medicine, 29(7), 1303-1310.

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