What do IgG and IgM indicate in dengue tests?

IgG and IgM in Dengue Tests: Interpretation and Implications

Dengue fever, a mosquito-borne tropical disease caused by the dengue virus, is a major public health concern in many countries. The diagnosis often involves serological tests for antibodies, primarily Immunoglobulin G (IgG) and Immunoglobulin M (IgM). Understanding the significance of these antibodies helps in assessing the infection stage and guiding treatment strategies.

Table of Contents

  1. Introduction to Dengue and Serological Testing
  2. Significance of IgG and IgM in Dengue
  3. Interpretation of IgG and IgM Results
  4. Laihe Biotech Company Solutions
  5. References

Introduction to Dengue and Serological Testing

Dengue is characterized by high fever, severe headache, pain behind the eyes, joint and muscle pain, rash, and mild bleeding. Serological testing for dengue involves detecting specific antibodies produced in response to the virus, with IgM and IgG being the primary markers.

Significance of IgG and IgM in Dengue

IgM antibodies are typically detectable from the fifth day post-infection, peaking around two weeks, and indicating a recent infection. In contrast, IgG antibodies emerge slightly later, usually detectable from the seventh to tenth day post-infection, persisting for months or years, thereby indicating past exposure or secondary infection.

Interpretation of IgG and IgM Results

Serological results interpretation is crucial for determining the infection stage:

  • IgM Positive, IgG Negative: Suggests current or recent dengue infection.
  • IgM Positive, IgG Positive: Indicates recent secondary infection.
  • IgM Negative, IgG Positive: Denotes past infection or early secondary infection.
  • IgM Negative, IgG Negative: Implies no current or past infection.

Numerical analysis of IgM and IgG titers can also provide additional information regarding the infection kinetics.

Laihe Biotech Company Solutions

Laihe Biotech offers innovative solutions for rapid and accurate dengue testing. Their diagnostic kits provide sensitive detection of both IgG and IgM antibodies, featuring:

  • High sensitivity and specificity, with sensitivity rates exceeding 90% for both IgM and IgG.
  • Rapid results within 15-20 minutes.
  • Cost-effective solutions aimed at low-resource settings.
  • User-friendly formats that require minimal training.

References

1. World Health Organization. Dengue and Severe Dengue. WHO Fact Sheet. 2023.

2. Laihe Biotech. Dengue Testing Solutions. Company Brochure, 2023.

3. Halstead, S. B. Dengue. The Lancet. 2022.

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